Pesquisa | Secretaria de Estado da Saúde

1.

Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection.

Anderson, Elizabeth M; Goodwin, Eileen C; Verma, Anurag; Arevalo, Claudia P; Bolton, Marcus J; Weirick, Madison E; Gouma, Sigrid; McAllister, Christopher M; Christensen, Shannon R; Weaver, JoEllen; Hicks, Philip; Manzoni, Tomaz B; Oniyide, Oluwatosin; Ramage, Holly; Mathew, Divij; Baxter, Amy E; Oldridge, Derek A; Greenplate, Allison R; Wu, Jennifer E; Alanio, Cécile; D'Andrea, Kurt; Kuthuru, Oliva; Dougherty, Jeanette; Pattekar, Ajinkya; Kim, Justin; Han, Nicholas; Apostolidis, Sokratis A; Huang, Alex C; Vella, Laura A; Kuri-Cervantes, Leticia; Pampena, M Betina; Betts, Michael R; Wherry, E John; Meyer, Nuala J; Cherry, Sara; Bates, Paul; Rader, Daniel J; Hensley, Scott E.

Cell ; 184(7): 1858-1864.e10, 2021 04 01.

Artigo Inglês | MEDLINE | ID: mdl-33631096

2.

Profound phenotypic and epigenetic heterogeneity of the HIV-1-infected CD4⁺ T cell reservoir.

Wu, Vincent H; Nordin, Jayme M L; Nguyen, Son; Joy, Jaimy; Mampe, Felicity; Del Rio Estrada, Perla M; Torres-Ruiz, Fernanda; González-Navarro, Mauricio; Luna-Villalobos, Yara Andrea; Ávila-Ríos, Santiago; Reyes-Terán, Gustavo; Tebas, Pablo; Montaner, Luis J; Bar, Katharine J; Vella, Laura A; Betts, Michael R.

Nat Immunol ; 24(2): 359-370, 2023 02.

Artigo Inglês | MEDLINE | ID: mdl-36536105

3.

Trimodal single-cell profiling reveals a novel pediatric CD8αα⁺ T cell subset and broad age-related molecular reprogramming across the T cell compartment.

Thomson, Zachary; He, Ziyuan; Swanson, Elliott; Henderson, Katherine; Phalen, Cole; Zaim, Samir Rachid; Pebworth, Mark-Phillip; Okada, Lauren Y; Heubeck, Alexander T; Roll, Charles R; Hernandez, Veronica; Weiss, Morgan; Genge, Palak C; Reading, Julian; Giles, Josephine R; Manne, Sasikanth; Dougherty, Jeanette; Jasen, C J; Greenplate, Allison R; Becker, Lynne A; Graybuck, Lucas T; Vasaikar, Suhas V; Szeto, Gregory L; Savage, Adam K; Speake, Cate; Buckner, Jane H; Li, Xiao-Jun; Bumol, Thomas F; Wherry, E John; Torgerson, Troy R; Vella, Laura A; Henrickson, Sarah E; Skene, Peter J; Gustafson, Claire E.

Nat Immunol ; 24(11): 1947-1959, 2023 Nov.

Artigo Inglês | MEDLINE | ID: mdl-37845489

4.

The Identity of Human Tissue-Emigrant CD8⁺ T Cells.

Buggert, Marcus; Vella, Laura A; Nguyen, Son; Wu, Vincent H; Chen, Zeyu; Sekine, Takuya; Perez-Potti, André; Maldini, Colby R; Manne, Sasikanth; Darko, Samuel; Ransier, Amy; Kuri-Cervantes, Leticia; Japp, Alberto Sada; Brody, Irene Bukh; Ivarsson, Martin A; Gorin, Jean-Baptiste; Rivera-Ballesteros, Olga; Hertwig, Laura; Antel, Jack P; Johnson, Matthew E; Okoye, Afam; Picker, Louis; Vahedi, Golnaz; Sparrelid, Ernesto; Llewellyn-Lacey, Sian; Gostick, Emma; Sandberg, Johan K; Björkström, Niklas; Bar-Or, Amit; Dori, Yoav; Naji, Ali; Canaday, David H; Laufer, Terri M; Wells, Andrew D; Price, David A; Frank, Ian; Douek, Daniel C; Wherry, E John; Itkin, Maxim G; Betts, Michael R.

Cell ; 183(7): 1946-1961.e15, 2020 12 23.

Artigo Inglês | MEDLINE | ID: mdl-33306960

5.

PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine.

Herati, Ramin Sedaghat; Knorr, David A; Vella, Laura A; Silva, Luisa Victoria; Chilukuri, Lakshmi; Apostolidis, Sokratis A; Huang, Alexander C; Muselman, Alexander; Manne, Sasikanth; Kuthuru, Oliva; Staupe, Ryan P; Adamski, Sharon A; Kannan, Senthil; Kurupati, Raj K; Ertl, Hildegund C J; Wong, Jeffrey L; Bournazos, Stylianos; McGettigan, Suzanne; Schuchter, Lynn M; Kotecha, Ritesh R; Funt, Samuel A; Voss, Martin H; Motzer, Robert J; Lee, Chung-Han; Bajorin, Dean F; Mitchell, Tara C; Ravetch, Jeffrey V; Wherry, E John.

Nat Immunol ; 23(8): 1183-1192, 2022 08.

Artigo Inglês | MEDLINE | ID: mdl-35902637

6.

Author Correction: Trimodal single-cell profiling reveals a novel pediatric CD8αα⁺ T cell subset and broad age-related molecular reprogramming across the T cell compartment.

Thomson, Zachary; He, Ziyuan; Swanson, Elliott; Henderson, Katherine; Phalen, Cole; Zaim, Samir Rachid; Pebworth, Mark-Phillip; Okada, Lauren Y; Heubeck, Alexander T; Roll, Charles R; Hernandez, Veronica; Weiss, Morgan; Genge, Palak C; Reading, Julian; Giles, Josephine R; Manne, Sasikanth; Dougherty, Jeanette; Jasen, C J; Greenplate, Allison R; Becker, Lynne A; Graybuck, Lucas T; Vasaikar, Suhas V; Szeto, Gregory L; Savage, Adam K; Speake, Cate; Buckner, Jane H; Li, Xiao-Jun; Bumol, Thomas F; Wherry, E John; Torgerson, Troy R; Vella, Laura A; Henrickson, Sarah E; Skene, Peter J; Gustafson, Claire E.

Nat Immunol ; 25(3): 577, 2024 Mar.

Artigo Inglês | MEDLINE | ID: mdl-38267693

7.

TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision.

Chen, Zeyu; Ji, Zhicheng; Ngiow, Shin Foong; Manne, Sasikanth; Cai, Zhangying; Huang, Alexander C; Johnson, John; Staupe, Ryan P; Bengsch, Bertram; Xu, Caiyue; Yu, Sixiang; Kurachi, Makoto; Herati, Ramin S; Vella, Laura A; Baxter, Amy E; Wu, Jennifer E; Khan, Omar; Beltra, Jean-Christophe; Giles, Josephine R; Stelekati, Erietta; McLane, Laura M; Lau, Chi Wai; Yang, Xiaolu; Berger, Shelley L; Vahedi, Golnaz; Ji, Hongkai; Wherry, E John.

Immunity ; 51(5): 840-855.e5, 2019 11 19.

Artigo Inglês | MEDLINE | ID: mdl-31606264

8.

Immunologic predictors of vaccine responsiveness in patients with lymphoma and CLL.

Chong, Elise A; Kumashie, Kingsley Gideon; Chong, Emeline R; Fabrizio, Joseph; Gupta, Aditi; Svoboda, Jakub; Barta, Stefan K; Walsh, Kristy M; Napier, Ellen B; Lundberg, Rachel K; Nasta, Sunita D; Gerson, James N; Landsburg, Daniel J; Gonzalez, Joyce; Gaano, Andrew; Weirick, Madison E; McAllister, Christopher M; Awofolaju, Moses; John, Gavin N; Kammerman, Shane C; Novaceck, Josef; Pajarillo, Raymone; Lundgreen, Kendall A; Tanenbaum, Nicole; Gouma, Sigrid; Drapeau, Elizabeth M; Adamski, Sharon; D'Andrea, Kurt; Pattekar, Ajinkya; Hicks, Amanda; Korte, Scott; Sharma, Harsh; Herring, Sarah; Williams, Justine C; Hamilton, Jacob T; Bates, Paul; Hensley, Scott E; Prak, Eline T Luning; Greenplate, Allison R; Wherry, E John; Schuster, Stephen J; Ruella, Marco; Vella, Laura A.

J Infect Dis ; 2024 Mar 04.

Artigo Inglês | MEDLINE | ID: mdl-38437622

9.

CMV infection and management among pediatric solid organ transplant recipients.

Downes, Kevin J; Sharova, Anna; Boge, Craig L K; Vader, Daniel; Mitrou, Marina; Hayes, Molly; Galetaki, Despoina M; Gianchetti, Lauren; Vella, Laura A; Li, Yun.

Pediatr Transplant ; 26(3): e14220, 2022 05.

Artigo Inglês | MEDLINE | ID: mdl-34994041

10.

Convalescent plasma for pediatric patients with SARS-CoV-2-associated acute respiratory distress syndrome.

Diorio, Caroline; Anderson, Elizabeth M; McNerney, Kevin O; Goodwin, Eileen C; Chase, Julie C; Bolton, Marcus J; Arevalo, Claudia P; Weirick, Madison E; Gouma, Sigrid; Vella, Laura A; Henrickson, Sarah E; Chiotos, Kathleen; Fitzgerald, Julie C; Kilbaugh, Todd J; John, Audrey R Odom; Blatz, Allison M; Lambert, Michele P; Sullivan, Kathleen E; Tartaglione, Margaret R; Zambrano, Danielle; Martin, Meghan; Lee, Jessica H; Young, Pampee; Friedman, David; Sesok-Pizzini, Deborah A; Hensley, Scott E; Behrens, Edward M; Bassiri, Hamid; Teachey, David T.

Pediatr Blood Cancer ; 67(11): e28693, 2020 11.

Artigo Inglês | MEDLINE | ID: mdl-32885904

11.

Metabolomic and Immunologic Discriminators of MIS-C at Emergency Room Presentation.

Vella, Laura A; Berna, Amalia Z; Blatz, Allison M; Logan, Joey; Sharma, Priya; Liu, Yang; Tedesco, Jonathan; Toland, Cara; Babiker, Leena; Hafertepe, Kathryn; Kammerman, Shane; Novacek, Josef; Akaho, Elikplim; Gonzalez, Alexander K; Taylor, Deanne; Diorio, Caroline; Balamuth, Fran; Bassiri, Hamid; Odom John, Audrey R.

medRxiv ; 2024 Jan 15.

Artigo Inglês | MEDLINE | ID: mdl-38293197

12.

IgA deficiency destabilizes homeostasis toward intestinal microbes and increases systemic immune dysregulation.

Conrey, Peyton E; Denu, Lidiya; O'Boyle, Kaitlin C; Rozich, Isaiah; Green, Jamal; Maslanka, Jeffrey; Lubin, Jean-Bernard; Duranova, Tereza; Haltzman, Brittany L; Gianchetti, Lauren; Oldridge, Derek A; De Luna, Nina; Vella, Laura A; Allman, David; Spergel, Jonathan M; Tanes, Ceylan; Bittinger, Kyle; Henrickson, Sarah E; Silverman, Michael A.

Sci Immunol ; 8(83): eade2335, 2023 05 26.

Artigo Inglês | MEDLINE | ID: mdl-37235682

13.

Healthy individuals have T-cell and antibody responses to the tumor antigen cyclin B1 that when elicited in mice protect from cancer.

Vella, Laura A; Yu, Min; Fuhrmann, Steven R; El-Amine, Moustapha; Epperson, Diane E; Finn, Olivera J.

Proc Natl Acad Sci U S A ; 106(33): 14010-5, 2009 Aug 18.

Artigo Inglês | MEDLINE | ID: mdl-19666607

14.

Signaling Through FcÎ³RIIA and the C5a-C5aR Pathway Mediate Platelet Hyperactivation in COVID-19.

Apostolidis, Sokratis A; Sarkar, Amrita; Giannini, Heather M; Goel, Rishi R; Mathew, Divij; Suzuki, Aae; Baxter, Amy E; Greenplate, Allison R; Alanio, Cécile; Abdel-Hakeem, Mohamed; Oldridge, Derek A; Giles, Josephine R; Wu, Jennifer E; Chen, Zeyu; Huang, Yinghui Jane; Belman, Jonathan; Pattekar, Ajinkya; Manne, Sasikanth; Kuthuru, Oliva; Dougherty, Jeanette; Weiderhold, Brittany; Weisman, Ariel R; Ittner, Caroline A G; Gouma, Sigrid; Dunbar, Debora; Frank, Ian; Huang, Alexander C; Vella, Laura A; Reilly, John P; Hensley, Scott E; Rauova, Lubica; Zhao, Liang; Meyer, Nuala J; Poncz, Mortimer; Abrams, Charles S; Wherry, E John.

Front Immunol ; 13: 834988, 2022.

Artigo Inglês | MEDLINE | ID: mdl-35309299

15.

Current Insights Into the Pathophysiology of Multisystem Inflammatory Syndrome in Children.

Vella, Laura A; Rowley, Anne H.

Curr Pediatr Rep ; 9(4): 83-92, 2021.

Artigo Inglês | MEDLINE | ID: mdl-34692237

16.

Vaccine-induced ICOS⁺CD38⁺ circulating Tfh are sensitive biosensors of age-related changes in inflammatory pathways.

Herati, Ramin Sedaghat; Silva, Luisa Victoria; Vella, Laura A; Muselman, Alexander; Alanio, Cecile; Bengsch, Bertram; Kurupati, Raj K; Kannan, Senthil; Manne, Sasikanth; Kossenkov, Andrew V; Canaday, David H; Doyle, Susan A; Ertl, Hildegund C J; Schmader, Kenneth E; Wherry, E John.

Cell Rep Med ; 2(5): 100262, 2021 05 18.

Artigo Inglês | MEDLINE | ID: mdl-34095875

17.

Proteomic Profiling of MIS-C Patients Reveals Heterogeneity Relating to Interferon Gamma Dysregulation and Vascular Endothelial Dysfunction.

Diorio, Caroline; Shraim, Rawan; Vella, Laura A; Giles, Josephine R; Baxter, Amy E; Oldridge, Derek A; Canna, Scott W; Henrickson, Sarah E; McNerney, Kevin O; Balamuth, Frances; Burudpakdee, Chakkapong; Lee, Jessica; Leng, Tomas; Farrell, Alvin; Lambert, Michele P; Sullivan, Kathleen E; John Wherry, E; Teachey, David T; Bassiri, Hamid; Behrens, Edward M.

medRxiv ; 2021 Apr 20.

Artigo Inglês | MEDLINE | ID: mdl-33907759

18.

Proteomic profiling of MIS-C patients indicates heterogeneity relating to interferon gamma dysregulation and vascular endothelial dysfunction.

Diorio, Caroline; Shraim, Rawan; Vella, Laura A; Giles, Josephine R; Baxter, Amy E; Oldridge, Derek A; Canna, Scott W; Henrickson, Sarah E; McNerney, Kevin O; Balamuth, Frances; Burudpakdee, Chakkapong; Lee, Jessica; Leng, Tomas; Farrel, Alvin; Lambert, Michele P; Sullivan, Kathleen E; Wherry, E John; Teachey, David T; Bassiri, Hamid; Behrens, Edward M.

Nat Commun ; 12(1): 7222, 2021 12 10.

Artigo Inglês | MEDLINE | ID: mdl-34893640

19.

Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) Antibody Responses in Children With Multisystem Inflammatory Syndrome in Children (MIS-C) and Mild and Severe Coronavirus Disease 2019 (COVID-19).

Anderson, Elizabeth M; Diorio, Caroline; Goodwin, Eileen C; McNerney, Kevin O; Weirick, Madison E; Gouma, Sigrid; Bolton, Marcus J; Arevalo, Claudia P; Chase, Julie; Hicks, Philip; Manzoni, Tomaz B; Baxter, Amy E; Andrea, Kurt P; Burudpakdee, Chakkapong; Lee, Jessica H; Vella, Laura A; Henrickson, Sarah E; Harris, Rebecca M; Wherry, E John; Bates, Paul; Bassiri, Hamid; Behrens, Edward M; Teachey, David T; Hensley, Scott E.

J Pediatric Infect Dis Soc ; 10(5): 669-673, 2021 May 28.

Artigo Inglês | MEDLINE | ID: mdl-33263756

20.

Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19.

Vella, Laura A; Giles, Josephine R; Baxter, Amy E; Oldridge, Derek A; Diorio, Caroline; Kuri-Cervantes, Leticia; Alanio, Cécile; Pampena, M Betina; Wu, Jennifer E; Chen, Zeyu; Huang, Yinghui Jane; Anderson, Elizabeth M; Gouma, Sigrid; McNerney, Kevin O; Chase, Julie; Burudpakdee, Chakkapong; Lee, Jessica H; Apostolidis, Sokratis A; Huang, Alexander C; Mathew, Divij; Kuthuru, Oliva; Goodwin, Eileen C; Weirick, Madison E; Bolton, Marcus J; Arevalo, Claudia P; Ramos, Andre; Jasen, C J; Conrey, Peyton E; Sayed, Samir; Giannini, Heather M; D'Andrea, Kurt; Meyer, Nuala J; Behrens, Edward M; Bassiri, Hamid; Hensley, Scott E; Henrickson, Sarah E; Teachey, David T; Betts, Michael R; Wherry, E John.

Sci Immunol ; 6(57)2021 03 02.

Artigo Inglês | MEDLINE | ID: mdl-33653907

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